The Combined Repetitive Oligopeptides of Clostridium difficile Toxin A Counteract Premature Cleavage of the Glucosyl-Transferase Domain by Stabilizing Protein Conformation

Toxin A (TcdA) and B (TcdB) from Clostridium difficile enter host cells by receptor-mediated endocytosis. A prerequisite for proper toxin action is the intracellular release of the glucosyltransferase domain by an inherent cysteine protease, which is allosterically activated by inositol hexaphosphat...

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Detalles Bibliográficos
Autores principales: Olling, Alexandra, Hüls, Corinna, Goy, Sebastian, Müller, Mirco, Krooss, Simon, Rudolf, Isa, Tatge, Helma, Gerhard, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113749/
https://www.ncbi.nlm.nih.gov/pubmed/25054784
http://dx.doi.org/10.3390/toxins6072162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113749/
https://www.ncbi.nlm.nih.gov/pubmed/25054784
http://dx.doi.org/10.3390/toxins6072162

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