Cargando…

The Combined Repetitive Oligopeptides of Clostridium difficile Toxin A Counteract Premature Cleavage of the Glucosyl-Transferase Domain by Stabilizing Protein Conformation

Toxin A (TcdA) and B (TcdB) from Clostridium difficile enter host cells by receptor-mediated endocytosis. A prerequisite for proper toxin action is the intracellular release of the glucosyltransferase domain by an inherent cysteine protease, which is allosterically activated by inositol hexaphosphat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olling, Alexandra, Hüls, Corinna, Goy, Sebastian, Müller, Mirco, Krooss, Simon, Rudolf, Isa, Tatge, Helma, Gerhard, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113749/ https://www.ncbi.nlm.nih.gov/pubmed/25054784 http://dx.doi.org/10.3390/toxins6072162

Ejemplares similares

The Repetitive Oligopeptide Sequences Modulate Cytopathic Potency but Are Not Crucial for Cellular Uptake of Clostridium difficile Toxin A
por: Olling, Alexandra, et al.
Publicado: (2011)

The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains
por: Beer, Lara-Antonia, et al.
Publicado: (2018)

Potential of an Enzyme Mixture of Glucose Oxidase, Glucosyl Transferase, and Fructosyl Transferase as an Antidiabetic Medicine
por: Kim, Daham, et al.
Publicado: (2021)

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
por: Quesada-Gómez, Carlos, et al.
Publicado: (2016)

Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
por: Henkel, Daniel, et al.
Publicado: (2020)

The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
por: Chung, Soo-Young, et al.
Publicado: (2018)

Identification of glucosyl transferase inhibitors from Psidium guajava against Streptococcus mutans in dental caries
por: Bhagavathy, S., et al.
Publicado: (2018)

Cytokinin glucosyl transferases, key regulators of cytokinin homeostasis, have potential value for wheat improvement
por: Chen, Lei, et al.
Publicado: (2021)

Glucosyl anthranilate
por: Liu, Haoyan, et al.
Publicado: (2009)

False-Positive Clostridium difficile in Negative-Control Reactions Peak and Then Decrease with Repetitive Refrigeration of Immunoassay
por: Rodriguez-Palacios, Alexander, et al.
Publicado: (2014)

Evaluation of the Xpert Clostridium difficile Assay for the Diagnosis of Clostridium difficile Infection
por: Shin, Saeam, et al.
Publicado: (2012)

Etymologia: Clostridium difficile
Publicado: (2010)

Clostridium: Transmission difficile?
por: Harbarth, Stephan, et al.
Publicado: (2012)

Clostridium difficile Infection
por: Feuerstadt, Paul
Publicado: (2015)

Clostridium difficile infection
por: Geller, Stephen A., et al.
Publicado: (2014)

Clostridium difficile Infection
por: Magdesian, K. Gary
Publicado: (2003)

Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB
por: Ruhe, Frederike, et al.
Publicado: (2017)

Study on Cecropin B2 Production via Construct Bearing Intein Oligopeptide Cleavage Variants
por: Fang, Yi-Ting, et al.
Publicado: (2020)

Etiology of Infectious Diarrhea in Patients Tested for Clostridium difficile: If It Isn’t Clostridium difficile, What Is It?
por: Kwon, Jennie H, et al.
Publicado: (2017)

Ectopic expression of citrus UDP-GLUCOSYL TRANSFERASE gene enhances anthocyanin and proanthocyanidins contents and confers high light tolerance in Arabidopsis
por: Rao, Muhammad Junaid, et al.
Publicado: (2019)

Clostridioides difficile Toxin A-Induced Wnt/β-Catenin Pathway Inhibition Is Mediated by Rac1 Glucosylation
por: Martins, Conceição S., et al.
Publicado: (2020)

The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition
por: Petersen, Lara, et al.
Publicado: (2022)

Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
por: Genth, Harald, et al.
Publicado: (2018)

Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells
por: Craven, Ryan, et al.
Publicado: (2015)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Clostridium difficile infections in China()
por: Jin, Ke, et al.
Publicado: (2010)

The structure of the S-layer of Clostridium difficile
por: Bradshaw, William J., et al.
Publicado: (2017)

Clostridium difficile infection: review
por: Czepiel, Jacek, et al.
Publicado: (2019)

Clostridium difficile Causing Empyema
por: Mohamed, Abdalla, et al.
Publicado: (2018)

Controversies in Clostridium difficile testing
por: Fedorko, Daniel P.
Publicado: (2002)

Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection
por: Péchiné, Séverine, et al.
Publicado: (2018)

Accuracy of Xpert Clostridium difficile assay for the diagnosis of Clostridium difficile infection: A meta analysis
por: Bai, Yuanyuan, et al.
Publicado: (2017)

Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile
por: Bolukcu, Sibel, et al.
Publicado: (2019)

Molecular Modeling and docking of Wheat Hydroquinone Glucosyl transferase by using Hydroquinone, Phenyl phosphorodiamate and n-(n butyl) Phosphorothiocic Triamide as Inhibitors
por: Huma, Tayyaba, et al.
Publicado: (2014)

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S(N)i Mechanism and Ion Pair Transition State
por: Paparella, Ashleigh S., et al.
Publicado: (2022)

Comparison of Supplemented Brucella Agar and Modified Clostridium difficile Agar for Antimicrobial Susceptibility Testing of Clostridium difficile
por: Kim, Gye Hyeong, et al.
Publicado: (2014)

The emergence of Clostridium difficile ribotypes 027 and 176 with a predominance of the Clostridium difficile ribotype 001 recognized in Slovakia following the European standardized Clostridium difficile infection surveillance of 2016
por: Novakova, Elena, et al.
Publicado: (2020)

Glucosylation of Isoflavonoids in Engineered Escherichia coli
por: Pandey, Ramesh Prasad, et al.
Publicado: (2014)

Aerial Dissemination of Clostridium difficile spores
por: Roberts, Katherine, et al.
Publicado: (2008)

Clostridium difficile: the increasingly difficult pathogen
por: Pop-Vicas, Aurora, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_a2c8lkli1b9efrr8gv7g3kdeuq