Lamellarin O, a Pyrrole Alkaloid from an Australian Marine Sponge, Ianthella sp., Reverses BCRP Mediated Drug Resistance in Cancer Cells

ATP binding cassette (ABC) transporters, such as P-gp, BCRP and MRP1, can increase efflux of clinical chemotherapeutic agents and lead to multi-drug resistance (MDR) in cancer cells. While the discovery and development of clinically useful inhibitors has proved elusive to date, this molecular target...

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Detalles Bibliográficos
Autores principales: Huang, Xiao-Cong, Xiao, Xue, Zhang, Yun-Kai, Talele, Tanaji T., Salim, Angela A., Chen, Zhe-Sheng, Capon, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113800/
https://www.ncbi.nlm.nih.gov/pubmed/24979269
http://dx.doi.org/10.3390/md12073818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113800/
https://www.ncbi.nlm.nih.gov/pubmed/24979269
http://dx.doi.org/10.3390/md12073818

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