Synapse Density and Dendritic Complexity Are Reduced in the Prefrontal Cortex following Seven Days of Forced Abstinence from Cocaine Self-Administration

Chronic cocaine exposure in both human addicts and in rodent models of addiction reduces prefrontal cortical activity, which subsequently dysregulates reward processing and higher order executive function. The net effect of this impaired gating of behavior is enhanced vulnerability to relapse. Previ...

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Detalles Bibliográficos
Autores principales: Rasakham, Khampaseuth, Schmidt, Heath D., Kay, Kevin, Huizenga, Megan N., Calcagno, Narghes, Pierce, R. Christopher, Spires-Jones, Tara L., Sadri-Vakili, Ghazaleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114454/
https://www.ncbi.nlm.nih.gov/pubmed/25072653
http://dx.doi.org/10.1371/journal.pone.0102524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114454/
https://www.ncbi.nlm.nih.gov/pubmed/25072653
http://dx.doi.org/10.1371/journal.pone.0102524

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