Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

To better understand the factors that influence the activity and specificity of antisense oligonucleotides (ASOs), we designed a minigene encoding superoxide dismutase 1 (SOD-1) and cloned the minigene into vectors for T7 transcription of pre-mRNA and splicing in a nuclear extract or for stable inte...

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Detalles Bibliográficos
Autores principales: Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114480/
https://www.ncbi.nlm.nih.gov/pubmed/25072142
http://dx.doi.org/10.1371/journal.pone.0101752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114480/
https://www.ncbi.nlm.nih.gov/pubmed/25072142
http://dx.doi.org/10.1371/journal.pone.0101752

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