N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture

Palladium-activated prodrug therapy is an experimental therapeutic approach that relies on the unique chemical properties and biocompatibility of heterogeneous palladium catalysis to enable the spatially-controlled in vivo conversion of a biochemically-stable prodrug into its active form. This strat...

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Detalles Bibliográficos
Autores principales: Weiss, Jason T., Fraser, Craig, Rubio-Ruiz, Belén, Myers, Samuel H., Crispin, Richard, Dawson, John C., Brunton, Valerie G., Patton, E. Elizabeth, Carragher, Neil O., Unciti-Broceta, Asier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114543/
https://www.ncbi.nlm.nih.gov/pubmed/25121087
http://dx.doi.org/10.3389/fchem.2014.00056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114543/
https://www.ncbi.nlm.nih.gov/pubmed/25121087
http://dx.doi.org/10.3389/fchem.2014.00056

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