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Carbon Monoxide Induces Heme Oxygenase-1 to Modulate STAT3 Activation in Endothelial Cells via S-Glutathionylation

IL-6/STAT3 pathway is involved in a variety of biological responses, including cell proliferation, differentiation, apoptosis, and inflammation. In our present study, we found that CO releasing molecules (CORMs) suppress IL-6-induced STAT3 phosphorylation, nuclear translocation and transactivity in...

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Detalles Bibliográficos
Autores principales: Yang, Yan-Chang, Huang, Yu-Ting, Hsieh, Chia-Wen, Yang, Po-Min, Wung, Being-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114553/
https://www.ncbi.nlm.nih.gov/pubmed/25072782
http://dx.doi.org/10.1371/journal.pone.0100677