Inhibitor-Induced Conformational Stabilization and Structural Alteration of a Mip-Like Peptidyl Prolyl cis-trans Isomerase and Its C-Terminal Domain

FKBP22, an Escherichia coli-encoded PPIase (peptidyl-prolyl cis-trans isomerase) enzyme, shares substantial identity with the Mip-like pathogenic factors, caries two domains, exists as a dimer in solution and binds some immunosuppressive drugs (such as FK506 and rapamycin) using its C-terminal domai...

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Detalles Bibliográficos
Autores principales: Polley, Soumitra, Jana, Biswanath, Chakrabarti, Gopal, Sau, Subrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114562/
https://www.ncbi.nlm.nih.gov/pubmed/25072141
http://dx.doi.org/10.1371/journal.pone.0102891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114562/
https://www.ncbi.nlm.nih.gov/pubmed/25072141
http://dx.doi.org/10.1371/journal.pone.0102891

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