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Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage

Selenocysteine (Sec) is encoded by an UGA codon with the help of a SECIS element present in selenoprotein mRNAs. SECIS-binding protein (SBP2/SCBP-2) mediates Sec insertion, but the roles of its domains and the impact of its deficiency on Sec insertion are not fully understood. We used Caenorhabditis...

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Detalles Bibliográficos
Autores principales: Otero, Lucía, Romanelli-Cedrez, Laura, Turanov, Anton A., Gladyshev, Vadim N., Miranda-Vizuete, Antonio, Salinas, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114682/
https://www.ncbi.nlm.nih.gov/pubmed/24817701
http://dx.doi.org/10.1261/rna.043877.113