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Disparate HDV ribozyme crystal structures represent intermediates on a rugged free-energy landscape

The hepatitis delta virus (HDV) ribozyme is a member of the class of small, self-cleaving catalytic RNAs found in a wide range of genomes from HDV to human. Both pre- and post-catalysis (precursor and product) crystal structures of the cis-acting genomic HDV ribozyme have been determined. These stru...

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Detalles Bibliográficos
Autores principales:	Sripathi, Kamali N., Tay, Wendy W., Banáš, Pavel, Otyepka, Michal, Šponer, Jiří, Walter, Nils G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114689/ https://www.ncbi.nlm.nih.gov/pubmed/24854621 http://dx.doi.org/10.1261/rna.044982.114

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