Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates

Nonenzymatic post-translational modification (PTM) of proteins is a fundamental molecular process of aging. The combination of various modifications and their accumulation with age not only affects function, but leads to crosslinking and protein aggregation. In this study, aged human lens proteins w...

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Detalles Bibliográficos
Autores principales: Wang, Zhen, Lyons, Brian, Truscott, Roger J W, Schey, Kevin L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114717/
https://www.ncbi.nlm.nih.gov/pubmed/24134651
http://dx.doi.org/10.1111/acel.12164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114717/
https://www.ncbi.nlm.nih.gov/pubmed/24134651
http://dx.doi.org/10.1111/acel.12164

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