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Increased blood–brain barrier permeability and alterations in perivascular astrocytes and pericytes induced by intracisternal glutaric acid

BACKGROUND: Glutaric acid (GA) is a dicarboxylic acid that accumulates in millimolar concentrations in glutaric acidemia I (GA-I), an inherited neurometabolic childhood disease characterized by extensive neurodegeneration. Vascular dysfunction is a common and early pathological feature in GA-I, alth...

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Detalles Bibliográficos
Autores principales:	Isasi, Eugenia, Barbeito, Luis, Olivera-Bravo, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115159/ https://www.ncbi.nlm.nih.gov/pubmed/25077029 http://dx.doi.org/10.1186/2045-8118-11-15

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