Direct Evidence for Calcineurin Binding to the Exon-7 Loop of the Sodium-Bicarbonate Cotransporter NBCn1

The NaHCO(3 )cotransporter NBCn1 plays a role in neutralizing intracellular acid loads at the basolateral membrane in cells of the medullary thick ascending limb (mTAL). Calcineurin inhibitors (Cn-Is) are known to both downregulate NBCn1 expression in the distal nephron and cause renal tubular acido...

Descripción completa

Detalles Bibliográficos
Autores principales: Gill, Harindarpal S., Roush, Eric D., Dutcher, Lauren, Patel, Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115197/
https://www.ncbi.nlm.nih.gov/pubmed/25076853
http://dx.doi.org/10.7150/ijbs.9539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115197/
https://www.ncbi.nlm.nih.gov/pubmed/25076853
http://dx.doi.org/10.7150/ijbs.9539

Ejemplares similares