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Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
The transcription factor Nrf2 is a master regulator of cellular defence: Nrf2 null mice (Nrf2((−/−))) are highly susceptible to chemically induced toxicities. We report a comparative iTRAQ-based study in Nrf2((−/−)) mice treated with a potent inducer, methyl-2-cyano-3,12-dioxooleana-1,9(11)dien-28-o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115266/ https://www.ncbi.nlm.nih.gov/pubmed/24859727 http://dx.doi.org/10.1016/j.jprot.2014.05.007 |