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Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

The transcription factor Nrf2 is a master regulator of cellular defence: Nrf2 null mice (Nrf2((−/−))) are highly susceptible to chemically induced toxicities. We report a comparative iTRAQ-based study in Nrf2((−/−)) mice treated with a potent inducer, methyl-2-cyano-3,12-dioxooleana-1,9(11)dien-28-o...

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Detalles Bibliográficos
Autores principales:	Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael, Olayanju, Adedamola, Powell, Helen, Copple, Ian, O’Neill, Paul M., Goldring, Christopher E.P., Kitteringham, Neil R., Park, B. Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115266/ https://www.ncbi.nlm.nih.gov/pubmed/24859727 http://dx.doi.org/10.1016/j.jprot.2014.05.007

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