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Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

BACKGROUND: Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of chromatin-related functions. Moreover, they are i...

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Detalles Bibliográficos
Autores principales:	Philpott, Martin, Rogers, Catherine M, Yapp, Clarence, Wells, Chris, Lambert, Jean-Philippe, Strain-Damerell, Claire, Burgess-Brown, Nicola A, Gingras, Anne-Claude, Knapp, Stefan, Müller, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115480/ https://www.ncbi.nlm.nih.gov/pubmed/25097667 http://dx.doi.org/10.1186/1756-8935-7-14

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