Rational Modification of Estrogen Receptor by Combination of Computational and Experimental Analysis

In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor-ligand complexes with computational analysis, we wer...

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Detalles Bibliográficos
Autores principales: Ferrero, Valentina Elisabetta Viviana, Pedotti, Mattia, Chiadò, Alessandro, Simonelli, Luca, Calzolai, Luigi, Varani, Luca, Lettieri, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116177/
https://www.ncbi.nlm.nih.gov/pubmed/25075862
http://dx.doi.org/10.1371/journal.pone.0102658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116177/
https://www.ncbi.nlm.nih.gov/pubmed/25075862
http://dx.doi.org/10.1371/journal.pone.0102658

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