Modulating Drug Resistance by Targeting BCRP/ABCG2 Using Retrovirus-Mediated RNA Interference

BACKGROUND: The BCRP/ABCG2 transporter, which mediates drug resistance in many types of cells, depends on energy provided by ATP hydrolysis. Here, a retrovirus encoding a shRNA targeting the ATP-binding domain of this protein was used to screen for highly efficient agents that could reverse drug res...

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Detalles Bibliográficos
Autores principales: Xie, Ni, Mou, Lisha, Yuan, Jianhui, Liu, Wenlan, Deng, Tingting, Li, Zigang, Jin, Yi, Hu, Zhangli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116202/
https://www.ncbi.nlm.nih.gov/pubmed/25076217
http://dx.doi.org/10.1371/journal.pone.0103463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116202/
https://www.ncbi.nlm.nih.gov/pubmed/25076217
http://dx.doi.org/10.1371/journal.pone.0103463

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