N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

A switch in the conformational properties of α-synuclein (αS) is hypothesized to be a key step in the pathogenic mechanism of Parkinson’s disease (PD). Whereas the beta-sheet-rich state of αS has long been associated with its pathological aggregation in PD, a partially alpha-helical state was found...

Descripción completa

Detalles Bibliográficos
Autores principales: Bartels, Tim, Kim, Nora C., Luth, Eric S., Selkoe, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116227/
https://www.ncbi.nlm.nih.gov/pubmed/25075858
http://dx.doi.org/10.1371/journal.pone.0103727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116227/
https://www.ncbi.nlm.nih.gov/pubmed/25075858
http://dx.doi.org/10.1371/journal.pone.0103727

Ejemplares similares