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Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration

Cells sense gradients of extracellular cues and generate polarized responses such as cell migration and neurite initiation. There is static information on the intracellular signaling molecules involved in these responses, but how they dynamically orchestrate polarized cell behaviors is not well unde...

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Detalles Bibliográficos
Autores principales: O'Neill, Patrick R., Gautam, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116304/
https://www.ncbi.nlm.nih.gov/pubmed/24920824
http://dx.doi.org/10.1091/mbc.E14-04-0870