FUS-regulated RNA metabolism and DNA damage repair: Implications for amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis

Cytoplasmic inclusion of RNA binding protein FUS/TLS in neurons and glial cells is a characteristic pathology of a subgroup of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dysregulation of RNA metabolism caused by FUS cytoplasmic inclusion emerges to be a key event in FUS-a...

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Detalles Bibliográficos
Autores principales: Zhou, Yueqin, Liu, Songyan, Öztürk, Arzu, Hicks, Geoffrey G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116389/
https://www.ncbi.nlm.nih.gov/pubmed/25083344
http://dx.doi.org/10.4161/rdis.29515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116389/
https://www.ncbi.nlm.nih.gov/pubmed/25083344
http://dx.doi.org/10.4161/rdis.29515

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