Cargando…

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

Attenuated growth hormone and insulin-like growth factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed. We tested the hypothesis that IGF-1 levels in nonagenarians...

Descripción completa

Detalles Bibliográficos
Autores principales:	Milman, Sofiya, Atzmon, Gil, Huffman, Derek M, Wan, Junxiang, Crandall, Jill P, Cohen, Pinchas, Barzilai, Nir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Short Takes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116456/ https://www.ncbi.nlm.nih.gov/pubmed/24618355 http://dx.doi.org/10.1111/acel.12213

Ejemplares similares

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

The influence of gender on inheritance of exceptional longevity
por: Deluty, Jennifer A., et al.
Publicado: (2015)

Integrity of hypothalamic–pituitary‐testicular axis in exceptional longevity
por: Aleksic, Sandra, et al.
Publicado: (2022)

The role of dietary patterns and exceptional parental longevity in healthy aging
por: Gubbi, Sriram, et al.
Publicado: (2017)

Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs
por: Waters, David J, et al.
Publicado: (2009)

Exome sequencing of three cases of familial exceptional longevity
por: Cash, Timothy P, et al.
Publicado: (2014)

Exceptional longevity is associated with decreased reproduction
por: Tabatabaie, Vafa, et al.
Publicado: (2011)

Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional Longevity without compromise to muscle mass and function
por: Perice, Leland, et al.
Publicado: (2016)

Association between Sleep Patterns and Health in Families with Exceptional Longevity
por: Klein, Lavy, et al.
Publicado: (2017)

The Hypothalamic-Pituitary-Testicular Axis in Exceptionally Old Men
por: Aleksic, Sandra, et al.
Publicado: (2021)

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
por: Kulkarni, Ameya S, et al.
Publicado: (2018)

IGF-I regulates the age-dependent signaling peptide humanin
por: Lee, Changhan, et al.
Publicado: (2014)

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity
por: Gutman, Danielle, et al.
Publicado: (2020)

Has gene duplication impacted the evolution of Eutherian longevity?
por: Doherty, Aoife, et al.
Publicado: (2016)

Genetic interaction with temperature is an important determinant of nematode longevity
por: Miller, Hillary, et al.
Publicado: (2017)

MicroRNAs mir‐184 and let‐7 alter Drosophila metabolism and longevity
por: Gendron, Christi M., et al.
Publicado: (2017)

Immunochip analysis identifies association of the RAD50/IL13 region with human longevity
por: Flachsbart, Friederike, et al.
Publicado: (2016)

Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice
por: Mendias, Christopher L, et al.
Publicado: (2015)

Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO
por: Park, Sangsoon, et al.
Publicado: (2020)

Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans
por: Atzmon, Gil, et al.
Publicado: (2006)

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress
por: Page, Melissa M, et al.
Publicado: (2014)

Female XX sex chromosomes increase survival and extend lifespan in aging mice
por: Davis, Emily J., et al.
Publicado: (2018)

In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles
por: Eitan, Erez, et al.
Publicado: (2017)

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction
por: Walaszczyk, Anna, et al.
Publicado: (2019)

Genetics, lifestyle and longevity: Lessons from centenarians
por: Govindaraju, Diddahally, et al.
Publicado: (2015)

Age-related variation in immunity in a wild mammal population
por: Nussey, Daniel H, et al.
Publicado: (2012)

Diet restriction‐induced healthy aging is mediated through the immune signaling component ZIP‐2 in Caenorhabditis elegans
por: Hahm, Jeong‐Hoon, et al.
Publicado: (2019)

Rapid senescence‐like response after acute injury
por: Chu, Xiaogang, et al.
Publicado: (2020)

Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty
por: Sathyan, Sanish, et al.
Publicado: (2018)

The antagonistic pleiotropy of insulin‐like growth factor 1
por: Zhang, William B., et al.
Publicado: (2021)

OR25-01 Longitudinal Changes in the Hypothalamic-Pituitary-Testicular (HPT) Axis in Men with Longevity
por: He, Diana, et al.
Publicado: (2023)

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells
por: Mohanty, Sarthak, et al.
Publicado: (2019)

Targeting RAS‐converting enzyme 1 overcomes senescence and improves progeria‐like phenotypes of ZMPSTE24 deficiency
por: Yao, Haidong, et al.
Publicado: (2020)

Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress
por: Chew, Yee Lian, et al.
Publicado: (2015)

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature
por: Ben-Avraham, Danny, et al.
Publicado: (2017)

Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells
por: Zhang, Haiping, et al.
Publicado: (2019)

The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells
por: Chen, Yu, et al.
Publicado: (2020)

Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR‐132/MeCP2 pathway
por: Xie, Ao‐Ji, et al.
Publicado: (2019)

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity
por: Fortney, Kristen, et al.
Publicado: (2015)

New horizons in life extension, healthspan extension and exceptional longevity
por: Couteur, David G Le, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5rhike2pvdevpj4l6ur6v1041b