Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

Carcinogenesis and neoplastic progression are mediated by the accumulation of somatic mutations. Here we report that the local density of somatic mutations in cancer genomes is highly reduced specifically in accessible regulatory DNA defined by DNase I hypersensitive sites. This reduction is indepen...

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Detalles Bibliográficos
Autores principales: Polak, Paz, Lawrence, Michael S., Haugen, Eric, Stoletzki, Nina, Stojanov, Petar, Thurman, Robert E, Garraway, Levi A., Mirkin, Sergei, Getz, Gad, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116484/
https://www.ncbi.nlm.nih.gov/pubmed/24336318
http://dx.doi.org/10.1038/nbt.2778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116484/
https://www.ncbi.nlm.nih.gov/pubmed/24336318
http://dx.doi.org/10.1038/nbt.2778

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