Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer

Chromosome maintenance region 1 (CRM1) also called Exportin 1 (Xpo1), a protein found elevated in pancreatic ductal adenocarcinoma (PDAC), blocks tumor suppressor protein (TSP) function through constant nuclear export. Earlier we had shown that targeting CRM1 by our newly developed specific inhibito...

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Detalles Bibliográficos
Autores principales: Gao, Jiankun, Azmi, Asfar S., Aboukameel, Amro, Kauffman, Michael, Shacham, Sharon, Abou-Samra, Abdul-Badi, Mohammad, Ramzi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116494/
https://www.ncbi.nlm.nih.gov/pubmed/24899509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116494/
https://www.ncbi.nlm.nih.gov/pubmed/24899509

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