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Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer
Chromosome maintenance region 1 (CRM1) also called Exportin 1 (Xpo1), a protein found elevated in pancreatic ductal adenocarcinoma (PDAC), blocks tumor suppressor protein (TSP) function through constant nuclear export. Earlier we had shown that targeting CRM1 by our newly developed specific inhibito...
Autores principales: | Gao, Jiankun, Azmi, Asfar S., Aboukameel, Amro, Kauffman, Michael, Shacham, Sharon, Abou-Samra, Abdul-Badi, Mohammad, Ramzi M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116494/ https://www.ncbi.nlm.nih.gov/pubmed/24899509 |
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