Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition

Dysfunctions of the mitochondria and the ubiquitin–proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the order of these events remains unclear. Here, we show that the initial impairment occurs in mitochon...

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Detalles Bibliográficos
Autores principales: Maharjan, Sunita, Oku, Masahide, Tsuda, Masashi, Hoseki, Jun, Sakai, Yasuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116626/
https://www.ncbi.nlm.nih.gov/pubmed/25077633
http://dx.doi.org/10.1038/srep05896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116626/
https://www.ncbi.nlm.nih.gov/pubmed/25077633
http://dx.doi.org/10.1038/srep05896

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