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Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition
Dysfunctions of the mitochondria and the ubiquitin–proteasome system, as well as generation of reactive oxygen species (ROS), are linked to many aging-related neurodegenerative disorders. However, the order of these events remains unclear. Here, we show that the initial impairment occurs in mitochon...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116626/ https://www.ncbi.nlm.nih.gov/pubmed/25077633 http://dx.doi.org/10.1038/srep05896 |