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The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
The ubiquitin-proteasome system (UPS) has been implicated in neurodegenerative diseases based on the presence of deposits consisting of ubiquitylated proteins in affected neurons. It has been postulated that aggregation-prone proteins associated with these disorders, such as α-synuclein, β-amyloid p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117186/ https://www.ncbi.nlm.nih.gov/pubmed/25132814 http://dx.doi.org/10.3389/fnmol.2014.00070 |