Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity

Receptor tyrosine kinase KIT controls many signal transduction pathways and represents a typical allosterically regulated protein. The mutation-induced deregulation of KIT activity impairs cellular physiological functions and causes serious human diseases. The impact of hotspots mutations (D816H/Y/N...

Descripción completa

Detalles Bibliográficos
Autores principales: Chauvot de Beauchêne, Isaure, Allain, Ariane, Panel, Nicolas, Laine, Elodie, Trouvé, Alain, Dubreuil, Patrice, Tchertanov, Luba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117417/
https://www.ncbi.nlm.nih.gov/pubmed/25079768
http://dx.doi.org/10.1371/journal.pcbi.1003749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117417/
https://www.ncbi.nlm.nih.gov/pubmed/25079768
http://dx.doi.org/10.1371/journal.pcbi.1003749

Ejemplares similares