Algorithms to Model Single Gene, Single Chromosome, and Whole Genome Copy Number Changes Jointly in Tumor Phylogenetics

We present methods to construct phylogenetic models of tumor progression at the cellular level that include copy number changes at the scale of single genes, entire chromosomes, and the whole genome. The methods are designed for data collected by fluorescence in situ hybridization (FISH), an experim...

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Detalles Bibliográficos
Autores principales: Chowdhury, Salim Akhter, Shackney, Stanley E., Heselmeyer-Haddad, Kerstin, Ried, Thomas, Schäffer, Alejandro A., Schwartz, Russell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117424/
https://www.ncbi.nlm.nih.gov/pubmed/25078894
http://dx.doi.org/10.1371/journal.pcbi.1003740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117424/
https://www.ncbi.nlm.nih.gov/pubmed/25078894
http://dx.doi.org/10.1371/journal.pcbi.1003740

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