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Regulation of Feto-Maternal Barrier by Matriptase- and PAR-2-Mediated Signaling Is Required for Placental Morphogenesis and Mouse Embryonic Survival

The development of eutherian mammalian embryos is critically dependent on the selective bi-directional transport of molecules across the placenta. Here, we uncover two independent and partially redundant protease signaling pathways that include the membrane-anchored serine proteases, matriptase and...

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Detalles Bibliográficos
Autores principales: Szabo, Roman, Peters, Diane E., Kosa, Peter, Camerer, Eric, Bugge, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117450/
https://www.ncbi.nlm.nih.gov/pubmed/25078604
http://dx.doi.org/10.1371/journal.pgen.1004470