MUC1 Positive, Kras and Pten Driven Mouse Gynecologic Tumors Replicate Human Tumors and Vary in Survival and Nuclear Grade Based on Anatomical Location

Activating mutations of Kras oncogene and deletions of Pten tumor suppressor gene play important roles in cancers of the female genital tract. We developed here new preclinical models for gynecologic cancers, using conditional (Cre-loxP) mice with floxed genetic alterations in Kras and Pten. The tri...

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Detalles Bibliográficos
Autores principales: Tirodkar, Tejas S., Budiu, Raluca A., Elishaev, Esther, Zhang, Lixin, Mony, Jyothi T., Brozick, Joan, Edwards, Robert P., Vlad, Anda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117479/
https://www.ncbi.nlm.nih.gov/pubmed/25078979
http://dx.doi.org/10.1371/journal.pone.0102409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117479/
https://www.ncbi.nlm.nih.gov/pubmed/25078979
http://dx.doi.org/10.1371/journal.pone.0102409

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