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Involvement of Fatty Acid Amide Hydrolase and Fatty Acid Binding Protein 5 in the Uptake of Anandamide by Cell Lines with Different Levels of Fatty Acid Amide Hydrolase Expression: A Pharmacological Study

BACKGROUND: The endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake, indicating that the enzyme regulates uptake b...

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Detalles Bibliográficos
Autores principales: Björklund, Emmelie, Blomqvist, Anders, Hedlin, Joel, Persson, Emma, Fowler, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117496/
https://www.ncbi.nlm.nih.gov/pubmed/25078278
http://dx.doi.org/10.1371/journal.pone.0103479