Localized interleukin-12 delivery for immunotherapy of solid tumours

Interleukin (IL)-12 is the key cytokine in the initiation of a Th1 response and has shown promise as an anti-cancer agent; however, clinical trials involving IL-12 have been unsuccessful due to toxic side-effects. To address this issue, lentiviral vectors were used to transduce tumour cell lines tha...

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Detalles Bibliográficos
Autores principales: Wei, Louis Z, Xu, Yixin, E Nelles, Megan, Furlonger, Caren, Wang, James CM, Di Grappa, Marco A, Khokha, Rama, Medin, Jeffrey A, Paige, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117559/
https://www.ncbi.nlm.nih.gov/pubmed/24251770
http://dx.doi.org/10.1111/jcmm.12121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117559/
https://www.ncbi.nlm.nih.gov/pubmed/24251770
http://dx.doi.org/10.1111/jcmm.12121

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