Insights from Molecular Dynamics Simulations: Structural Basis for the V567D Mutation-Induced Instability of Zebrafish Alpha-Dystroglycan and Comparison with the Murine Model

A missense amino acid mutation of valine to aspartic acid in 567 position of alpha-dystroglycan (DG), identified in dag1-mutated zebrafish, results in a reduced transcription and a complete absence of the protein. Lacking experimental structural data for zebrafish DG domains, the detailed mechanism...

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Detalles Bibliográficos
Autores principales: Pirolli, Davide, Sciandra, Francesca, Bozzi, Manuela, Giardina, Bruno, Brancaccio, Andrea, De Rosa, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117597/
https://www.ncbi.nlm.nih.gov/pubmed/25078606
http://dx.doi.org/10.1371/journal.pone.0103866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117597/
https://www.ncbi.nlm.nih.gov/pubmed/25078606
http://dx.doi.org/10.1371/journal.pone.0103866

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