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A Molecularly Cloned, Live-Attenuated Japanese Encephalitis Vaccine SA(14)-14-2 Virus: A Conserved Single Amino Acid in the ij Hairpin of the Viral E Glycoprotein Determines Neurovirulence in Mice
Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes fatal neurological disease in humans, is one of the most important emerging pathogens of public health significance. JEV represents the JE serogroup, which also includes West Nile, Murray Valley encephalitis, and St. Louis en...
Autores principales: | Yun, Sang-Im, Song, Byung-Hak, Kim, Jin-Kyoung, Yun, Gil-Nam, Lee, Eun-Young, Li, Long, Kuhn, Richard J., Rossmann, Michael G., Morrey, John D., Lee, Young-Min |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117607/ https://www.ncbi.nlm.nih.gov/pubmed/25077483 http://dx.doi.org/10.1371/journal.ppat.1004290 |
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