The TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis elegans

The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the severity of this locomotor phenotype. Our initial findi...

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Detalles Bibliográficos
Autores principales: Khabirova, Eleonora, Moloney, Aileen, Marciniak, Stefan J., Williams, Julie, Lomas, David A., Oliver, Stephen G., Favrin, Giorgio, Sattelle, David B., Crowther, Damian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117641/
https://www.ncbi.nlm.nih.gov/pubmed/25080104
http://dx.doi.org/10.1371/journal.pone.0102985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117641/
https://www.ncbi.nlm.nih.gov/pubmed/25080104
http://dx.doi.org/10.1371/journal.pone.0102985

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