Cargando…

Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation

DNA methylation is a central epigenetic modification in mammals, with essential roles in development and disease. De novo DNA methyltransferases establish DNA methylation patterns in specific regions within the genome by mechanisms that remain poorly understood. Here we show that protein citrullinat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deplus, Rachel, Denis, Hélène, Putmans, Pascale, Calonne, Emilie, Fourrez, Marie, Yamamoto, Kazuhiko, Suzuki, Akari, Fuks, François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117755/ https://www.ncbi.nlm.nih.gov/pubmed/24957603 http://dx.doi.org/10.1093/nar/gku522

Ejemplares similares

The histone demethylase Kdm3a is essential to progression through differentiation
por: Herzog, Marielle, et al.
Publicado: (2012)

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
por: Felle, Max, et al.
Publicado: (2011)

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
por: Veland, Nicolas, et al.
Publicado: (2019)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
por: Van Emburgh, Beth O., et al.
Publicado: (2011)

The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation
por: Recalde, Miriam, et al.
Publicado: (2021)

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L
por: Jurkowska, Renata Z., et al.
Publicado: (2008)

Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
por: Stepper, Peter, et al.
Publicado: (2017)

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail
por: Zhang, Yingying, et al.
Publicado: (2010)

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing
por: O’Geen, Henriette, et al.
Publicado: (2022)

Transient DNMT1 suppression reveals hidden heritable marks in the genome
por: McGraw, Serge, et al.
Publicado: (2015)

Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
por: Dukatz, Michael, et al.
Publicado: (2020)

Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling
por: Schneider, Katrin, et al.
Publicado: (2013)

On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase
por: Adam, Sabrina, et al.
Publicado: (2023)

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
por: Thompson, Joyce J, et al.
Publicado: (2018)

Dnmt1 binds and represses genomic retroelements via DNA methylation in mouse early embryos
por: Min, Byungkuk, et al.
Publicado: (2020)

Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP
por: Zhang, Yuxia, et al.
Publicado: (2012)

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
por: Espada, Jesús, et al.
Publicado: (2011)

SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
por: Zhang, Huifang, et al.
Publicado: (2019)

GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair
por: Lee, Bongyong, et al.
Publicado: (2012)

ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing
por: Gatto, Sole, et al.
Publicado: (2017)

A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association
por: Han, Mengmeng, et al.
Publicado: (2020)

A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
por: Shen, Li, et al.
Publicado: (2010)

Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
por: Patel, Katan, et al.
Publicado: (2010)

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression
por: Estève, Pierre-Olivier, et al.
Publicado: (2016)

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts
por: Zhang, Donghong, et al.
Publicado: (2017)

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
por: Clements, Eriko G., et al.
Publicado: (2012)

GSK-3484862 targets DNMT1 for degradation in cells
por: Chen, Qin, et al.
Publicado: (2023)

Effects of DNA methylation on nucleosome stability
por: Collings, Clayton K., et al.
Publicado: (2013)

RTEL1 is required for silencing and epigenome stability
por: Olivier, Margaux, et al.
Publicado: (2023)

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
por: Hu, Huifang, et al.
Publicado: (2020)

On the stability of stalled RNA polymerase and its removal by RapA
por: Portman, James R, et al.
Publicado: (2022)

Tagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex
por: Yuzenkova, Yulia, et al.
Publicado: (2013)

Low RNA stability signifies strong expression regulatability of tumor suppressors
por: Gao, Xinlei, et al.
Publicado: (2023)

Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress
por: Servant, Géraldine, et al.
Publicado: (2012)

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
por: Sarkies, Peter, et al.
Publicado: (2012)

bHLH proteins involved in Drosophila neurogenesis are mutually regulated at the level of stability
por: Kiparaki, Marianthi, et al.
Publicado: (2015)

Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1
por: Evans, Emma L., et al.
Publicado: (2011)

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes
por: Li, Yanqiang, et al.
Publicado: (2023)

The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome
por: Chakravarthy, Srinivas, et al.
Publicado: (2012)

DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin
por: Murugesapillai, Divakaran, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vtc00p4dddv8rpknsg1m42iftd