MegaTevs: single-chain dual nucleases for efficient gene disruption

Targeting gene disruptions in complex genomes relies on imprecise repair by the non-homologous end-joining DNA pathway, creating mutagenic insertions or deletions (indels) at the break point. DNA end-processing enzymes are often co-expressed with genome-editing nucleases to enhance the frequency of...

Descripción completa

Detalles Bibliográficos
Autores principales: Wolfs, Jason M., DaSilva, Matthew, Meister, Sarah E., Wang, Xu, Schild-Poulter, Caroline, Edgell, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117789/
https://www.ncbi.nlm.nih.gov/pubmed/25013171
http://dx.doi.org/10.1093/nar/gku573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117789/
https://www.ncbi.nlm.nih.gov/pubmed/25013171
http://dx.doi.org/10.1093/nar/gku573

Ejemplares similares