Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

The sequence of events leading to stress granule assembly in stressed cells remains elusive. We show here, using isotope labeling and ion microprobe, that proportionally more RNA than proteins are present in stress granules than in surrounding cytoplasm. We further demonstrate that the delivery of s...

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Detalles Bibliográficos
Autores principales: Bounedjah, Ouissame, Desforges, Bénédicte, Wu, Ting-Di, Pioche-Durieu, Catherine, Marco, Sergio, Hamon, Loic, Curmi, Patrick A., Guerquin-Kern, Jean-Luc, Piétrement, Olivier, Pastré, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117795/
https://www.ncbi.nlm.nih.gov/pubmed/25013173
http://dx.doi.org/10.1093/nar/gku582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117795/
https://www.ncbi.nlm.nih.gov/pubmed/25013173
http://dx.doi.org/10.1093/nar/gku582

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