Loss of wild-type Jak2 allele enhances myeloid cell expansion and accelerates myelofibrosis in Jak2V617F knock-in mice

JAK2V617F is the most common mutation found in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). Although a majority of MPN patients carry heterozygous JAK2V617F mutation, loss of heterozygosity (LOH) on chromosome 9p involving the JAK2 locus has been observed in ~30% of MPN pati...

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Detalles Bibliográficos
Autores principales: Akada, Hajime, Akada, Saeko, Hutchison, Robert E., Mohi, Golam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117831/
https://www.ncbi.nlm.nih.gov/pubmed/24480985
http://dx.doi.org/10.1038/leu.2014.52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117831/
https://www.ncbi.nlm.nih.gov/pubmed/24480985
http://dx.doi.org/10.1038/leu.2014.52

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