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Kinetic Hairpin Oligonucleotide Blockers for Selective Amplification of Rare Mutations

Detection of rare mutant alleles in an excess of wild type alleles is increasingly important in cancer diagnosis. Several methods for selective amplification of a mutant allele via the polymerase chain reaction (PCR) have been reported, but each of these methods has its own limitations. A common pro...

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Detalles Bibliográficos
Autores principales: Jia, Yanwei, Sanchez, J. Aquiles, Wangh, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118197/
https://www.ncbi.nlm.nih.gov/pubmed/25082368
http://dx.doi.org/10.1038/srep05921