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Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats

Alzheimer's disease (AD) and cerebral ischaemia share similar features in terms of altered amyloid precursor protein (APP) processing and β-amyloid (Aβ) accumulation. We have previously shown that Aβ and calcium deposition, and β-secretase activity, are robustly increased in the ipsilateral tha...

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Detalles Bibliográficos
Autores principales: Sarajärvi, Timo, Lipsanen, Anu, Mäkinen, Petra, Peräniemi, Sirpa, Soininen, Hilkka, Haapasalo, Annakaisa, Jolkkonen, Jukka, Hiltunen, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118244/
https://www.ncbi.nlm.nih.gov/pubmed/22805236
http://dx.doi.org/10.1111/j.1582-4934.2012.01599.x