Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence

Cellular senescence, which is known to halt proliferation of aged and stressed cells, plays a key role against cancer development and is also closely associated with organismal aging. While increased insulin-like growth factor (IGF) signaling induces cell proliferation, survival and cancer progressi...

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Detalles Bibliográficos
Autores principales: Tran, Duc, Bergholz, Johann, Zhang, Haibo, He, Hanbing, Wang, Yang, Zhang, Yujun, Li, Qintong, Kirkland, James L, Xiao, Zhi-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118446/
https://www.ncbi.nlm.nih.gov/pubmed/25070626
http://dx.doi.org/10.1111/acel.12219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118446/
https://www.ncbi.nlm.nih.gov/pubmed/25070626
http://dx.doi.org/10.1111/acel.12219

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