IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis

BACKGROUND: The Akita mutation (C96Y) in the insulin gene results in early onset diabetes in both humans and mice. Expression of mutant proinsulin (C96Y) causes endoplasmic reticulum (ER) stress in pancreatic β-cells and consequently the cell activates the unfolded protein response (UPR). Since the...

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Detalles Bibliográficos
Autores principales: Zhang, Liling, Nosak, Courtney, Sollazzo, Pietro, Odisho, Tanya, Volchuk, Allen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118655/
https://www.ncbi.nlm.nih.gov/pubmed/25011481
http://dx.doi.org/10.1186/1471-2121-15-29

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118655/
https://www.ncbi.nlm.nih.gov/pubmed/25011481
http://dx.doi.org/10.1186/1471-2121-15-29

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