Structural and biophysical analysis of interactions between cod and human uracil-DNA N-glycosylase (UNG) and UNG inhibitor (Ugi)

Uracil-DNA N-glycosylase from Atlantic cod (cUNG) shows cold-adapted features such as high catalytic efficiency, a low temperature optimum for activity and reduced thermal stability compared with its mesophilic homologue human UNG (hUNG). In order to understand the role of the enzyme–substrate inter...

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Detalles Bibliográficos
Autores principales: Assefa, Netsanet Gizaw, Niiranen, Laila, Johnson, Kenneth A., Leiros, Hanna-Kirsti Schrøder, Smalås, Arne Oskar, Willassen, Nils Peder, Moe, Elin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118823/
https://www.ncbi.nlm.nih.gov/pubmed/25084329
http://dx.doi.org/10.1107/S1399004714011699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118823/
https://www.ncbi.nlm.nih.gov/pubmed/25084329
http://dx.doi.org/10.1107/S1399004714011699

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