Sequencing and G-Quadruplex Folding of the Canine Proto-Oncogene KIT Promoter Region: Might Dog Be Used as a Model for Human Disease?

Downregulation of gene expression by induction of non-canonical DNA structures at promotorial level is a novel attractive anticancer strategy. In human, two guanine-rich sequences (h_kit1 and h_kit2) were identified in the promotorial region of oncogene KIT. Their stabilization into G-quadruplex str...

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Detalles Bibliográficos
Autores principales: Da Ros, Silvia, Zorzan, Eleonora, Giantin, Mery, Zorro Shahidian, Lara, Palumbo, Manlio, Dacasto, Mauro, Sissi, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118953/
https://www.ncbi.nlm.nih.gov/pubmed/25084283
http://dx.doi.org/10.1371/journal.pone.0103876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118953/
https://www.ncbi.nlm.nih.gov/pubmed/25084283
http://dx.doi.org/10.1371/journal.pone.0103876

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