Women with the Alzheimer's risk marker ApoE4 lose Aβ-specific CD4(+) T cells 10–20 years before men

Adaptive immunity to self-antigens causes autoimmune disorders, such as multiple sclerosis, psoriasis and type 1 diabetes; paradoxically, T- and B-cell responses to amyloid-β (Aβ) reduce Alzheimer's disease (AD)-associated pathology and cognitive impairment in mouse models of the disease. The m...

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Detalles Bibliográficos
Autores principales: Begum, A N, Cunha, C, Sidhu, H, Alkam, T, Scolnick, J, Rosario, E R, Ethell, D W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119219/
https://www.ncbi.nlm.nih.gov/pubmed/25072319
http://dx.doi.org/10.1038/tp.2014.51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119219/
https://www.ncbi.nlm.nih.gov/pubmed/25072319
http://dx.doi.org/10.1038/tp.2014.51

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