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Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents

Cognitive decline is one of the many characteristics of aging. Reduced long-term potentiation (LTP) and long-term depression (LTD) are thought to be responsible for this decline, although the precise mechanisms underlying LTP and LTD dampening in the old remain unclear. We previously showed that agi...

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Detalles Bibliográficos
Autores principales: Martin, Mauricio G, Ahmed, Tariq, Korovaichuk, Alejandra, Venero, Cesar, Menchón, Silvia A, Salas, Isabel, Munck, Sebastian, Herreras, Oscar, Balschun, Detlef, Dotti, Carlos G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119354/
https://www.ncbi.nlm.nih.gov/pubmed/24878762
http://dx.doi.org/10.15252/emmm.201303711