Cargando…

Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents

Cognitive decline is one of the many characteristics of aging. Reduced long-term potentiation (LTP) and long-term depression (LTD) are thought to be responsible for this decline, although the precise mechanisms underlying LTP and LTD dampening in the old remain unclear. We previously showed that agi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Mauricio G, Ahmed, Tariq, Korovaichuk, Alejandra, Venero, Cesar, Menchón, Silvia A, Salas, Isabel, Munck, Sebastian, Herreras, Oscar, Balschun, Detlef, Dotti, Carlos G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119354/ https://www.ncbi.nlm.nih.gov/pubmed/24878762 http://dx.doi.org/10.15252/emmm.201303711

Ejemplares similares

Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
por: Martín‐Segura, Adrián, et al.
Publicado: (2019)

Can pathway-specific LFPs be obtained in cytoarchitectonically complex structures?
por: Makarova, Julia, et al.
Publicado: (2014)

Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice
por: Callaerts-Vegh, Zsuzsanna, et al.
Publicado: (2015)

What Constitutes Rodent Ulcer?
por: Walker, Norman
Publicado: (1893)

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling
por: Fazzari, Pietro, et al.
Publicado: (2014)

APM_GUI: analyzing particle movement on the cell membrane and determining confinement
por: Menchón, Silvia A, et al.
Publicado: (2012)

Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity
por: Latif-Hernandez, Amira, et al.
Publicado: (2016)

Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs
por: Latif-Hernandez, Amira, et al.
Publicado: (2016)

TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons
por: Menigoz, Aurélie, et al.
Publicado: (2015)

Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models
por: Faldini, Enrico, et al.
Publicado: (2019)

Reverse engineering of metabotropic glutamate receptor-dependent long-term depression in the hippocampus
por: Tambuyzer, Tim, et al.
Publicado: (2011)

Distinct Properties of Long-Term Potentiation in the Dentate Gyrus along the Dorsoventral Axis: Influence of Age and Inhibition
por: Schreurs, An, et al.
Publicado: (2017)

Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism
por: Martín-Segura, Adrián, et al.
Publicado: (2019)

Constitutive and Stress-induced Expression of CCL5 Machinery in Rodent Retina
por: Duncan, D'Anne S., et al.
Publicado: (2017)

Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer’s Disease
por: Samaey, Celine, et al.
Publicado: (2019)

Orchestrated ensemble activities constitute a hippocampal memory engram
por: Ghandour, Khaled, et al.
Publicado: (2019)

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
por: McLeod, Faye, et al.
Publicado: (2017)

The two faces of synaptic failure in App(NL-G-F) knock-in mice
por: Latif-Hernandez, Amira, et al.
Publicado: (2020)

Methionine sulfoxide reductases and cholesterol transporter STARD3 constitute an efficient system for detoxification of cholesterol hydroperoxides
por: Lim, Jung Mi, et al.
Publicado: (2023)

Uncorrelated bilateral cortical input becomes timed across hippocampal subfields for long waves whereas gamma waves are largely ipsilateral
por: Hernández-Recio, Sara, et al.
Publicado: (2023)

Definition of constitutive and stage-enriched promoters in the rodent malaria parasite, Plasmodium yoelii
por: Bowman, Laura M., et al.
Publicado: (2020)

Constitutive accessibility of circulating proteins to hippocampal neurons in physiologically normal rats
por: Hamasaki, Sawako, et al.
Publicado: (2020)

Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy
por: Ahmed, Tariq, et al.
Publicado: (2020)

Neuronal (Bi)Polarity as a Self-Organized Process Enhanced by Growing Membrane
por: Menchón, Silvia A., et al.
Publicado: (2011)

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase
por: Coates, Hudson W, et al.
Publicado: (2023)

Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer’s Disease
por: Vyas, Yukti, et al.
Publicado: (2020)

Neuromodulatory functions exerted by oxytocin on different populations of hippocampal neurons in rodents
por: Talpo, Francesca, et al.
Publicado: (2023)

Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity
por: Salas, Isabel H., et al.
Publicado: (2017)

Membrane Cholesterol Is a Critical Determinant for Hippocampal Neuronal Polarity
por: Jose, Mini, et al.
Publicado: (2021)

Local Field Potentials: Myths and Misunderstandings
por: Herreras, Oscar
Publicado: (2016)

Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity
por: Salas, Isabel H., et al.
Publicado: (2017)

Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity
por: Salas, Isabel H., et al.
Publicado: (2017)

Hippocampal Oscillations in the Rodent Model of Schizophrenia Induced by Amygdala GABA Receptor Blockade
por: Lanre-Amos, Tope, et al.
Publicado: (2010)

Comparative Hippocampal Synaptic Proteomes of Rodents and Primates: Differences in Neuroplasticity-Related Proteins
por: Koopmans, Frank, et al.
Publicado: (2018)

Uncovering spatial representations from spatiotemporal patterns of rodent hippocampal field potentials
por: Cao, Liang, et al.
Publicado: (2021)

Transferability of biotic interactions: Temporal consistency of arctic plant–rodent relationships is poor
por: Soininen, Eeva M., et al.
Publicado: (2018)

Habitat productivity is a poor predictor of body size in rodents
por: Alhajeri, Bader H, et al.
Publicado: (2020)

Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning
por: Navarro-López, Juan D., et al.
Publicado: (2022)

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form
por: Coates, Hudson W., et al.
Publicado: (2021)

Understanding the Impact of Dietary Cholesterol on Chronic Metabolic Diseases through Studies in Rodent Models
por: Vinué, Ángela, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q167m7ten8ouh1bv0cgv36ap4e